T cell subset-specific susceptibility to aging
M Czesnikiewicz-Guzik, WW Lee, D Cui, Y Hiruma… - Clinical …, 2008 - Elsevier
With increasing age, the competence of the immune system to fight infections and tumors
declines. Age-dependent changes have been mostly described for human CD8 T cells,
raising the question of whether the response patterns for CD4 T cells are different. Gene
expression arrays of memory CD4 T cells yielded a similar age-induced fingerprint as has
been described for CD8 T cells. In cross-sectional studies, the phenotypic changes were not
qualitatively different for CD4 and CD8 T cells, but occurred much more frequently in CD8 T …
declines. Age-dependent changes have been mostly described for human CD8 T cells,
raising the question of whether the response patterns for CD4 T cells are different. Gene
expression arrays of memory CD4 T cells yielded a similar age-induced fingerprint as has
been described for CD8 T cells. In cross-sectional studies, the phenotypic changes were not
qualitatively different for CD4 and CD8 T cells, but occurred much more frequently in CD8 T …