Chronic granulomatous disease is a neutrophil disorder in which phagocytic cells fail to
produce a respiratory burst. Five genetic types of chronic granulomatous disease have been
described and in each case the clinical manifestations relate to the inability to effectively kill
catalase-positive organisms. It is classically described as a pure disorder of intracellular
killing, with preservation of other aspects of phagocytic function such as migration and
phagocytosis and normal function of nonmyeloid cells. This article describes a heretofore …