[HTML][HTML] Antenatal membranous glomerulonephritis due to anti–neutral endopeptidase antibodies

H Debiec, V Guigonis, B Mougenot… - … England Journal of …, 2002 - Mass Medical Soc
H Debiec, V Guigonis, B Mougenot, F Decobert, JP Haymann, A Bensman, G Deschźnes…
New England Journal of Medicine, 2002Mass Medical Soc
The hallmark of membranous glomerulonephritis, a major primary nephropathy, is the
presence of immune deposits on the outer aspect of the glomerular basement membrane.
The cause of such deposits in humans has eluded detection. The authors of this report
studied a neonate whose nephropathy began in utero and who had renal failure and the
nephrotic syndrome at birth. Subsequent studies of the infant and his parents documented
that alloantibodies had developed in the mother after an earlier miscarriage and that she …
The hallmark of membranous glomerulonephritis, a major primary nephropathy, is the presence of immune deposits on the outer aspect of the glomerular basement membrane. The cause of such deposits in humans has eluded detection. The authors of this report studied a neonate whose nephropathy began in utero and who had renal failure and the nephrotic syndrome at birth. Subsequent studies of the infant and his parents documented that alloantibodies had developed in the mother after an earlier miscarriage and that she had a deficiency of neutral endopeptidase. Because she lacked neutral endopeptidase, nephropathy did not develop in the mother, but disease did develop in rabbits that were injected with IgG antibodies from the mother. These antibodies reacted with neutral endopeptidase and were colocalized in subepithelial immune deposits.
The New England Journal Of Medicine