[HTML][HTML] TRPC channels in smooth muscle cells

JC Gonzalez-Cobos, M Trebak - Frontiers in bioscience: a journal …, 2010 - ncbi.nlm.nih.gov
JC Gonzalez-Cobos, M Trebak
Frontiers in bioscience: a journal and virtual library, 2010ncbi.nlm.nih.gov
Transient receptor potential canonical (TRPC) proteins constitute a family of seven (TRPC1-
7) nonselective cation channels within the wider TRP superfamily. TRPC1, TRPC3, TRPC4,
TRPC5 and TRPC6 channels are expressed in vascular smooth muscle cells from human
vessels of all calibers and in smooth muscle from organs such as the uterus and the
gastrointestinal tract. TRPC channels have recently emerged as important players in the
control of smooth muscle function. This review will focus on the retrospective analysis of …
Abstract
Transient receptor potential canonical (TRPC) proteins constitute a family of seven (TRPC1-7) nonselective cation channels within the wider TRP superfamily. TRPC1, TRPC3, TRPC4, TRPC5 and TRPC6 channels are expressed in vascular smooth muscle cells from human vessels of all calibers and in smooth muscle from organs such as the uterus and the gastrointestinal tract. TRPC channels have recently emerged as important players in the control of smooth muscle function. This review will focus on the retrospective analysis of studies proposing contributions of TRPC channels to native calcium entry pathways in smooth muscle and to physiological and pathophysiological responses with emphasis on the vascular system.
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