Pericyte TIMP3 and ADAMTS1 modulate vascular stability after kidney injury

C Schrimpf, C Xin, G Campanholle, SE Gill… - Journal of the …, 2012 - journals.lww.com
Kidney pericytes are progenitors of scar-forming interstitial myofibroblasts that appear after
injury. The function of kidney pericytes as microvascular cells and how these cells detach
from peritubular capillaries and migrate to the interstitial space, however, are poorly
understood. Here, we used an unbiased approach to identify genes in kidney pericytes
relevant to detachment and differentiation in response to injury in vivo, with a particular focus
on genes regulating proteolytic activity and angiogenesis. Kidney pericytes rapidly activated …