Dll4, a novel Notch ligand expressed in arterial endothelium

JR Shutter, S Scully, W Fan, WG Richards… - Genes & …, 2000 - genesdev.cshlp.org
JR Shutter, S Scully, W Fan, WG Richards, J Kitajewski, GA Deblandre, CR Kintner, KL Stark
Genes & development, 2000genesdev.cshlp.org
We report the cloning and characterization of a new member of the Delta family of Notch
ligands, which we have named Dll4. Like other Delta genes, Dll4 is predicted to encode a
membrane-bound ligand, characterized by an extracellular region containing several EGF-
like domains and a DSL domain required for receptor binding. In situ analysis reveals a
highly selective expression pattern of Dll4 within the vascular endothelium. The activity and
expression of Dll4 and the known actions of other members of this family suggest a role for …
We report the cloning and characterization of a new member of the Delta family of Notch ligands, which we have named Dll4. Like other Delta genes, Dll4 is predicted to encode a membrane-bound ligand, characterized by an extracellular region containing several EGF-like domains and a DSL domain required for receptor binding. In situ analysis reveals a highly selective expression pattern of Dll4 within the vascular endothelium. The activity and expression of Dll4 and the known actions of other members of this family suggest a role for Dll4 in the control of endothelial cell biology.
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