Influence of estrogen plus progestin on breast cancer and mammography in healthy postmenopausal women: the Women's Health Initiative Randomized Trial

RT Chlebowski, SL Hendrix, RD Langer, ML Stefanick… - Jama, 2003 - jamanetwork.com
ContextThe Women's Health Initiative trial of combined estrogen plus progestin was stopped
early when overall health risks, including invasive breast cancer, exceeded benefits.
Outstanding issues not previously addressed include characteristics of breast cancers
observed among women using hormones and whether diagnosis may be influenced by
hormone effects on mammography. ObjectiveTo determine the relationship among estrogen
plus progestin use, breast cancer characteristics, and mammography recommendations …