The role of neuropeptide Y in energy homeostasis

AP Chambers, SC Woods - Appetite control, 2012 - Springer
AP Chambers, SC Woods
Appetite control, 2012Springer
When administered into the brain, NPY acts at Y1 and Y5 receptors to increase food intake.
The response occurs with a short latency and is quite robust, such that exogenous NPY is
generally considered to be the most potent of a growing list of orexigenic compounds that
act in the brain. The role of endogenous NPY is not so straightforward, however. Evidence
from diverse types of experiments suggests that rather than initiating behavioral eating per
se, endogenous NPY elicits autonomic responses that prepare the individual to better cope …
Abstract
When administered into the brain, NPY acts at Y1 and Y5 receptors to increase food intake. The response occurs with a short latency and is quite robust, such that exogenous NPY is generally considered to be the most potent of a growing list of orexigenic compounds that act in the brain. The role of endogenous NPY is not so straightforward, however. Evidence from diverse types of experiments suggests that rather than initiating behavioral eating per se, endogenous NPY elicits autonomic responses that prepare the individual to better cope with consuming a calorically large meal.
Springer