Abstract The Janus Kinase/Signal Transducers and Activators of Transcription (JAK/STAT)
signaling pathway is utilized by numerous cytokines and interferons, and is essential for the
development and function of both innate and adaptive immunity. Aberrant activation of the
JAK/STAT pathway is evident in neuroinflammatory diseases such as Multiple Sclerosis and
Parkinson's Disease. Innate immunity is the front line defender of the immune system and is
composed of various cell types, including microglia, macrophages and neutrophils. Innate …