Janus kinase 2 regulates transcription factor EB expression and autophagy completion in glomerular podocytes
TA Alghamdi, S Majumder, K Thieme… - Journal of the …, 2017 - journals.lww.com
The nonreceptor kinase Janus kinase 2 (JAK2) has garnered attention as a promising
therapeutic target for the treatment of CKD. However, being ubiquitously expressed in the
adult, JAK2 is also likely to be necessary for normal organ function. Here, we investigated
the phenotypic effects of JAK2 deficiency. Mice in which JAK2 had been deleted from
podocytes exhibited an elevation in urine albumin excretion that was accompanied by
increased podocyte autophagosome fractional volume and p62 aggregation, which are …
therapeutic target for the treatment of CKD. However, being ubiquitously expressed in the
adult, JAK2 is also likely to be necessary for normal organ function. Here, we investigated
the phenotypic effects of JAK2 deficiency. Mice in which JAK2 had been deleted from
podocytes exhibited an elevation in urine albumin excretion that was accompanied by
increased podocyte autophagosome fractional volume and p62 aggregation, which are …
