Regulation of SIRT2-dependent α-tubulin deacetylation by cellular NAD levels
RH Skoge, C Dölle, M Ziegler - DNA repair, 2014 - Elsevier
Acetylation of α-tubulin on lysine 40 is one of the major posttranslational modifications of
microtubules. The acetylation reaction is catalyzed by alpha-tubulin N-acetyltransferase and
the modification can be reversed by either the NAD-independent class II histone
deacetylase HDAC6 or the NAD-dependent deacetylase SIRT2. In this study, we assessed
to what extent cellular NAD levels are involved in the regulation of the α-tubulin acetylation
state. Cells were subjected to different treatments known to influence cellular NAD content …
microtubules. The acetylation reaction is catalyzed by alpha-tubulin N-acetyltransferase and
the modification can be reversed by either the NAD-independent class II histone
deacetylase HDAC6 or the NAD-dependent deacetylase SIRT2. In this study, we assessed
to what extent cellular NAD levels are involved in the regulation of the α-tubulin acetylation
state. Cells were subjected to different treatments known to influence cellular NAD content …
