[PDF][PDF] HMGB1: LPS delivery vehicle for caspase-11-mediated pyroptosis
Recognition of cytoplasmic lipopolysaccharide (LPS) by caspase-11 leads to pyroptosis and
secretion of inflammatory mediators. In this issue of Immunity, Deng et al.(2018) report that
high-mobility group box 1 (HMGB1) secreted by hepatocytes delivers extracellular LPS into
the cytoplasm and mediates pyroptosis.
secretion of inflammatory mediators. In this issue of Immunity, Deng et al.(2018) report that
high-mobility group box 1 (HMGB1) secreted by hepatocytes delivers extracellular LPS into
the cytoplasm and mediates pyroptosis.
Recognition of cytoplasmic lipopolysaccharide (LPS) by caspase-11 leads to pyroptosis and secretion of inflammatory mediators. In this issue of Immunity, Deng et al. (2018) report that high-mobility group box 1 (HMGB1) secreted by hepatocytes delivers extracellular LPS into the cytoplasm and mediates pyroptosis.
cell.com
