[HTML][HTML] Sialylation of glycosylphosphatidylinositol (GPI) anchors of mammalian prions is regulated in a host-, tissue-, and cell-specific manner
E Katorcha, S Srivastava, N Klimova… - Journal of Biological …, 2016 - ASBMB
Prions or PrP Sc are proteinaceous infectious agents that consist of misfolded, self-
replicating states of the prion protein or PrP C. PrP C is posttranslationally modified with N-
linked glycans and a sialylated glycosylphosphatidylinositol (GPI) anchor. Conformational
conversion of PrP C gives rise to glycosylated and GPI-anchored PrP Sc. The question of the
sialylation status of GPIs within PrP Sc has been controversial. Previous studies that
examined scrapie brains reported that both sialo-and asialo-GPIs were present in PrP Sc …
replicating states of the prion protein or PrP C. PrP C is posttranslationally modified with N-
linked glycans and a sialylated glycosylphosphatidylinositol (GPI) anchor. Conformational
conversion of PrP C gives rise to glycosylated and GPI-anchored PrP Sc. The question of the
sialylation status of GPIs within PrP Sc has been controversial. Previous studies that
examined scrapie brains reported that both sialo-and asialo-GPIs were present in PrP Sc …