Rapid desensitization of mice with anti-FcγRIIb/FcγRIII mAb safely prevents IgG-mediated anaphylaxis
MV Khodoun, ZY Kucuk, RT Strait… - Journal of allergy and …, 2013 - Elsevier
Background Stimulatory IgG receptors (FcγRs) on bone marrow-derived cells contribute to
the pathogenesis of several autoimmune and inflammatory disorders. Monoclonal
antibodies that block FcγRs might suppress these diseases, but they can induce
anaphylaxis. Objective We wanted to determine whether a rapid desensitization approach
can safely suppress IgG/FcγR-mediated anaphylaxis. Methods Mice were injected with
serially increasing doses of 2.4 G2, a rat mAb that blocks the inhibitory FcγR, FcγRIIb, and …
the pathogenesis of several autoimmune and inflammatory disorders. Monoclonal
antibodies that block FcγRs might suppress these diseases, but they can induce
anaphylaxis. Objective We wanted to determine whether a rapid desensitization approach
can safely suppress IgG/FcγR-mediated anaphylaxis. Methods Mice were injected with
serially increasing doses of 2.4 G2, a rat mAb that blocks the inhibitory FcγR, FcγRIIb, and …
