Mechanism underlying the suppressor activity of retinoic acid on IL4-induced IgE synthesis and its physiological implication
The present study extends an earlier report that retinoic acid (RA) down-regulates IgE Ab
synthesis in vitro. Here, we show the suppressive activity of RA on IgE production in vivo and
its underlying mechanisms. We found that RA down-regulated IgE class switching
recombination (CSR) mainly through RA receptor α (RARα). Additionally, RA inhibited
histone acetylation of germ-line ε (GL ε) promoter, leading to suppression of IgE CSR.
Consistently, serum IgE levels were substantially elevated in vitamin A-deficient (VAD) mice …
synthesis in vitro. Here, we show the suppressive activity of RA on IgE production in vivo and
its underlying mechanisms. We found that RA down-regulated IgE class switching
recombination (CSR) mainly through RA receptor α (RARα). Additionally, RA inhibited
histone acetylation of germ-line ε (GL ε) promoter, leading to suppression of IgE CSR.
Consistently, serum IgE levels were substantially elevated in vitamin A-deficient (VAD) mice …
