Regulation of lymphocyte survival by the bcl-2 gene family
S Cory - Annual review of immunology, 1995 - annualreviews.org
S Cory
Annual review of immunology, 1995•annualreviews.orgThe control of cell survival is of central importance in tissues with high cell turnover such as
the lymphoid system, and its disruption may be a critical step in tumorigenesis. Genes
homologous to bcl-2, the oncogene implicated in human follicular lymphoma, play a key role
in regulating physiologic cell death (apopto sis). Bcl-2 and its relatives bcl-x and bax encode
intracellular membrane-bound proteins that share homology in three domains with a wider
family of viral and cellular proteins. The Bcl-2 and Bcl-x proteins enhance the survival of …
the lymphoid system, and its disruption may be a critical step in tumorigenesis. Genes
homologous to bcl-2, the oncogene implicated in human follicular lymphoma, play a key role
in regulating physiologic cell death (apopto sis). Bcl-2 and its relatives bcl-x and bax encode
intracellular membrane-bound proteins that share homology in three domains with a wider
family of viral and cellular proteins. The Bcl-2 and Bcl-x proteins enhance the survival of …
Abstract
The control of cell survival is of central importance in tissues with high cell turnover such as the lymphoid system, and its disruption may be a critical step in tumorigenesis. Genes homologous to bcl-2, the oncogene implicated in human follicular lymphoma, play a key role in regulating physiologic cell death (apopto sis). Bcl-2 and its relatives bcl-x and bax encode intracellular membrane-bound proteins that share homology in three domains with a wider family of viral and cellular proteins. The Bcl-2 and Bcl-x proteins enhance the survival of lympho cytes and other cell types but do not promote their proliferation. High levels of Bax or of a smaller Bcl-x variant antagonize the survival function of Bcl-2.
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