[HTML][HTML] p47phox Phox homology domain regulates plasma membrane but not phagosome neutrophil NADPH oxidase activation
XJ Li, CC Marchal, ND Stull, RV Stahelin… - Journal of biological …, 2010 - ASBMB
The assembly of cytosolic subunits p47 phox, p67 phox, and p40 phox with flavocytochrome
b 558 at the membrane is required for activating the neutrophil NADPH oxidase that
generates superoxide for microbial killing. The p47 phox subunit plays a critical role in
oxidase assembly. Recent studies showed that the p47 phox Phox homology (PX) domain
mediates phosphoinositide binding in vitro and regulates phorbol ester-induced NADPH
oxidase activity in a K562 myeloid cell model. Because the importance of the p47 phox PX …
b 558 at the membrane is required for activating the neutrophil NADPH oxidase that
generates superoxide for microbial killing. The p47 phox subunit plays a critical role in
oxidase assembly. Recent studies showed that the p47 phox Phox homology (PX) domain
mediates phosphoinositide binding in vitro and regulates phorbol ester-induced NADPH
oxidase activity in a K562 myeloid cell model. Because the importance of the p47 phox PX …