[HTML][HTML] Toll-like receptor 7/8 agonists stimulate plasmacytoid dendritic cells to initiate TH17-deviated acute contact dermatitis in human subjects
N Garzorz-Stark, F Lauffer, L Krause, J Thomas… - Journal of Allergy and …, 2018 - Elsevier
Background A standardized human model to study early pathogenic events in patients with
psoriasis is missing. Activation of Toll-like receptor 7/8 by means of topical application of
imiquimod is the most commonly used mouse model of psoriasis. Objective We sought to
investigate the potential of a human imiquimod patch test model to resemble human
psoriasis. Methods Imiquimod (Aldara 5% cream; 3M Pharmaceuticals, St Paul, Minn) was
applied twice a week to the backs of volunteers (n= 18), and development of skin lesions …
psoriasis is missing. Activation of Toll-like receptor 7/8 by means of topical application of
imiquimod is the most commonly used mouse model of psoriasis. Objective We sought to
investigate the potential of a human imiquimod patch test model to resemble human
psoriasis. Methods Imiquimod (Aldara 5% cream; 3M Pharmaceuticals, St Paul, Minn) was
applied twice a week to the backs of volunteers (n= 18), and development of skin lesions …