Bone marrow–derived cells are sufficient and necessary targets to mediate glomerulonephritis and vasculitis induced by anti-myeloperoxidase antibodies
A Schreiber, H Xiao, RJ Falk… - Journal of the American …, 2006 - journals.lww.com
Clinical and experimental evidence indicate that ANCA cause pauci-immune necrotizing
and crescentic glomerulonephritis (NCGN) and systemic small vessel vasculitis in humans.
One of the major target antigens for ANCA is myeloperoxidase (MPO). An animal model that
closely resembles the human disease is induced by intravenous injection of anti-MPO IgG
into mice. The likely primary pathogenic targets for the anti-MPO IgG are circulating
neutrophils and monocytes, although other cells have been implicated, including endothelial …
and crescentic glomerulonephritis (NCGN) and systemic small vessel vasculitis in humans.
One of the major target antigens for ANCA is myeloperoxidase (MPO). An animal model that
closely resembles the human disease is induced by intravenous injection of anti-MPO IgG
into mice. The likely primary pathogenic targets for the anti-MPO IgG are circulating
neutrophils and monocytes, although other cells have been implicated, including endothelial …