Glioblastoma (GBM) is the most common and invasive primary brain cancer. GBM tumors
are characterized by diffuse infiltration, with tumor cells invading slowly through the
hyaluronic acid (HA)-rich parenchyma toward vascular beds and then migrating rapidly
along microvasculature. Progress in understanding local infiltration, vascular homing, and
perivascular invasion is limited by the absence of culture models that recapitulate these
hallmark processes. Here, we introduce a platform for GBM invasion consisting of a tumor …