[HTML][HTML] Expression of gamma-glutamyltransferase 1 in glioblastoma cells confers resistance to cystine deprivation–induced ferroptosis
K Hayashima, H Katoh - Journal of Biological Chemistry, 2022 - ASBMB
Ferroptosis is an iron-dependent mode of cell death caused by excessive oxidative damage
to lipids. Lipid peroxidation is normally suppressed by glutathione peroxidase 4, which
requires reduced glutathione. Cystine is a major resource for glutathione synthesis,
especially in cancer cells. Therefore, cystine deprivation or inhibition of cystine uptake
promotes ferroptosis in cancer cells. However, the roles of other molecules involved in
cysteine deprivation–induced ferroptosis are unexplored. We report here that the expression …
to lipids. Lipid peroxidation is normally suppressed by glutathione peroxidase 4, which
requires reduced glutathione. Cystine is a major resource for glutathione synthesis,
especially in cancer cells. Therefore, cystine deprivation or inhibition of cystine uptake
promotes ferroptosis in cancer cells. However, the roles of other molecules involved in
cysteine deprivation–induced ferroptosis are unexplored. We report here that the expression …