Chronic treatment with valproic acid or sodium butyrate attenuates novel object recognition deficits and hippocampal dendritic spine loss in a mouse model of autism
K Takuma, Y Hara, S Kataoka, T Kawanai… - Pharmacology …, 2014 - Elsevier
We recently showed that prenatal exposure to valproic acid (VPA) in mice causes autism-
like behavioral abnormalities, including social interaction deficits, anxiety-like behavior and
spatial learning disability, in male offspring. In the present study, we examined the effect of
prenatal VPA on cognitive function and whether the effect is improved by chronic treatment
with VPA and sodium butyrate, histone deacetylase inhibitors. In addition, we examined
whether the cognitive dysfunction is associated with hippocampal dendritic morphological …
like behavioral abnormalities, including social interaction deficits, anxiety-like behavior and
spatial learning disability, in male offspring. In the present study, we examined the effect of
prenatal VPA on cognitive function and whether the effect is improved by chronic treatment
with VPA and sodium butyrate, histone deacetylase inhibitors. In addition, we examined
whether the cognitive dysfunction is associated with hippocampal dendritic morphological …
