Hyaluronan induces monocyte chemoattractant protein-1 expression in renal tubular epithelial cells.
B Beck-Schimmer, B Oertli, T Pasch… - Journal of the …, 1998 - journals.lww.com
Hyaluronan (HA) is a nonsulfated glycosaminoglycan that accumulates in the renal
interstitium in immune-mediated kidney diseases. The functional significance of such HA
deposition in the kidney has not been elucidated. Several studies have suggested that HA
may exhibit proinflammatory effects. Since chemokines such as monocyte chemoattractant
protein-1 (MCP-1) play an important role in the recruitment of leukocytes in renal injury, this
study tested whether HA and its fragments could promote MCP-1 production by renal …
interstitium in immune-mediated kidney diseases. The functional significance of such HA
deposition in the kidney has not been elucidated. Several studies have suggested that HA
may exhibit proinflammatory effects. Since chemokines such as monocyte chemoattractant
protein-1 (MCP-1) play an important role in the recruitment of leukocytes in renal injury, this
study tested whether HA and its fragments could promote MCP-1 production by renal …
