[HTML][HTML] Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling
NRD Paling, H Wheadon, HK Bone… - Journal of Biological …, 2004 - ASBMB
The maintenance of murine embryonic stem (ES) cell self-renewal is regulated by leukemia
inhibitory factor (LIF)-dependent activation of signal transducer and activator of transcription
3 (STAT3) and LIF-independent mechanisms including Nanog, BMP2/4, and Wnt signaling.
Here we demonstrate a previously undescribed role for phosphoinositide 3-kinases (PI3Ks)
in regulation of murine ES cell self-renewal. Treatment with the reversible PI3K inhibitor,
LY294002, or more specific inhibition of class IA PI3K via regulated expression of dominant …
inhibitory factor (LIF)-dependent activation of signal transducer and activator of transcription
3 (STAT3) and LIF-independent mechanisms including Nanog, BMP2/4, and Wnt signaling.
Here we demonstrate a previously undescribed role for phosphoinositide 3-kinases (PI3Ks)
in regulation of murine ES cell self-renewal. Treatment with the reversible PI3K inhibitor,
LY294002, or more specific inhibition of class IA PI3K via regulated expression of dominant …