Large clonal expansions of CD8+ T cells in acute infectious mononucleosis
MFC Callan, N Steven, P Krausa, JDK Wilson… - Nature medicine, 1996 - nature.com
Nature medicine, 1996•nature.com
Abstract Primary infection with Epstein–Barr virus often results in the clinical syndrome of
acute infectious mononucleosis (glandular fever). This illness is characterized by a striking
lymphocytosis, the nature of which has been controversial. We show that large monoclonal
or oligoclonal populations of CD8+ T cells account for a significant proportion of the
lymphocytosis and provide molecular evidence that these populations have been driven by
antigen. The results suggest that the selective and massive expansion of a few dominant …
acute infectious mononucleosis (glandular fever). This illness is characterized by a striking
lymphocytosis, the nature of which has been controversial. We show that large monoclonal
or oligoclonal populations of CD8+ T cells account for a significant proportion of the
lymphocytosis and provide molecular evidence that these populations have been driven by
antigen. The results suggest that the selective and massive expansion of a few dominant …
Abstract
Primary infection with Epstein–Barr virus often results in the clinical syndrome of acute infectious mononucleosis (glandular fever). This illness is characterized by a striking lymphocytosis, the nature of which has been controversial. We show that large monoclonal or oligoclonal populations of CD8+ T cells account for a significant proportion of the lymphocytosis and provide molecular evidence that these populations have been driven by antigen. The results suggest that the selective and massive expansion of a few dominant clones of CD8+ T cells is an important feature of the primary response to this virus.
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